Back in October of 2022,
I wrote a blog post about
taking a break
from writing. Well, my break is over, and it’s good to be back! Although I
haven’t been writing over the past several months, that doesn’t mean I haven’t
been learning about writing. Sure, I have a BA, an MA, and a PhD in the
subject, but as
a
lifelong learner, I find there’s always something more I can learn
about any topic.
I’ve focused my recent
learning on medical writing. Put simply, there are two broad categories of
medical writing: writing about complex medical topics for a specialized
audience (such as with research articles in medical journals), and writing
about complex medical topics for a general audience. During my writing break,
I’ve done lots of reading of both kinds of medical writing, and this blog post
will be an example of the latter kind.
For a topic, I thought
it would be interesting to write about a condition called thoracic outlet
syndrome (TOS). Just a few months prior to the start of my writing break, it
was announced that prospective Major League Baseball player Cole
Henry was diagnosed with this condition and would be having surgery.
In this post, I’ll address what TOS is, who gets it, and how it’s treated.
What is TOS?
TOS is a condition in
which nerves, an artery, and/or a vein is compressed between the collarbone and
the first rib either on one side or on both sides of the body. As Dr. Julie
Freischlag, expert in TOS treatment and author of multiple articles about TOS,
and her colleague Dr. Kristine Orion explained in the article “Understanding
Thoracic Outlet Syndrome,” there are three types of TOS. In
neurogenic TOS (nTOS), the nerves passing through the area are compressed.
These nerves are called the brachial plexus, and they provide signals to the
arm and hand, both of which experience pain with this type of TOS. In venous
TOS (vTOS), the vein that passes between the collarbone and the first rib is
compressed, hindering the flow of blood from the heart to the arm, often
causing blood clots and pain. In arterial TOS (aTOS), the artery passing
between the collarbone and first rib is compressed, which not only causes pain
but also means blood flow from the arm back to the heart is compromised. The
nTOS type of TOS is the most common, affecting 95% of patients with TOS, while
aTOS is most rare, affecting only 1-2% of all TOS patients.
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Illustration of the
structures involved in thoracic outlet syndrome; missing in the illustration
are the neck muscles that attach to the first rib. (Wikimedia
Commons/BruceBlaus)
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What Causes TOS?
Drs. Freischlag and
Orion noted in their article several common causes of TOS. One is some sort of
injury to the area, such as from a car crash or a fall. Another is repetitive
use of the arms, whether due to work requirements or leisure activities, such
as participation in sports or playing an instrument. Still another cause is having
a unique anatomy, such as having an extra rib above the first rib that
contributes to compression. While the causes of TOS in general have become more
well understood in recent years, what is not as well understood is why some
people develop nTOS, others vTOS, and still others aTOS. More research in this
area is needed.
Who Gets TOS?
Several professional
athletes have made the news for their TOS diagnoses. In addition to baseball
pitcher Cole Henry, a number of other professional baseball pitchers have been
diagnosed with TOS, including Major Leaguers Chris
Carpenter, Phil
Hughes, and Matt
Harvey, to name a few. But baseball pitchers are not the only
professional athletes to have been diagnosed with TOS. Notably, NBA player Markelle
Fultz of the Philadelphia 76ers received his diagnosis of nTOS in
2018.
In addition to these
famous cases of TOS, another famous figure, country music star Eric
Church, was also diagnosed
with the condition in 2018. In Church’s case, symptoms of numbness and swelling
led to the discovery of a clot and his diagnosis with vTOS. These cases of TOS
in those who have achieved fame show that this medical condition can affect
anyone with a narrowing of the thoracic outlet, but how widespread is TOS in
the general population?
A recently published
research study addressed
that question. According to the authors, TOS is a rare condition. Based on
their research, they estimated that only about 25 out of a million people have
nTOS, while only about eight in a million have vTOS. With aTOS accounting for
only 1-2% of all TOS patients, we can calculate that fewer than one in a
million people have aTOS.
How is TOS Treated?
TOS specialist Dr.
Freischlag and her colleague Dr. Orion noted in their article that treatment
for TOS progresses through several stages. The first step is achieving an
accurate diagnosis, and in cases of nTOS, this is best achieved through a
physical examination as well as an injection of the numbing agent lidocaine
into the scalene muscle in the neck. If this procedure relieves pain, then the
doctor can be reasonably sure that TOS is the cause of the problem. In cases of
vTOS or aTOS, a blockage of the vein or artery found through ultrasound can
eliminate the need for the diagnostic injection.
Once an accurate
diagnosis is achieved, the doctors explained that patients without a clot
generally proceed to treatment with physical therapy and pain relieving
medication. In 60-70% of people with TOS, such treatment is sufficient to solve
the problem. Those with a vein or artery blockage usually skip this step and
proceed directly to surgery.
For those whose
symptoms are not fully relieved with physical therapy and pain-relieving
medication, Drs. Freischlag and Orion described an additional possible step in
treatment, injection with Botox. This injection is followed by more physical
therapy. If all of these treatments have failed, surgery is the final option.
The aim of TOS surgery
is to remove the first rib and the scalene muscle in the neck to relieve the
compression of the thoracic outlet. There are two approaches to the surgery,
one that uses an incision near the collar bone and one that uses an incision in
the armpit. A study published in January 2023 in the
Journal of Vascular Surgery: Venous
and Lymphatic Disorders comparing the two approaches showed both had
excellent outcomes.
For those interested in
more details about how surgeries using the two approaches are conducted,
several descriptions are available online. For example, Dr. Freischlag
described the armpit approach in a podcast
interview, and
the podcast also published a
video showing Dr.
Fresichlag conducting a surgery using this approach. (
Warning: Because the video is
graphic, viewers must sign in to their Google account in order to verify they
are an adult in order to view it.) Also, a video showing the approach near the
collar bone has been published by the
Journal of
Vascular Surgery: Cases, Innovations and Techniques.
(Warning: Although the
page containing this video features graphic images and the video itself is just
as graphic as the one illustrating the armpit approach, there are no viewing
restrictions, so readers are encouraged to use caution when opting to view this
material.)
Possible Failures or Complications of Surgery
All surgeries involve
risk, and TOS surgery is no exception. Although Drs. Freischlag and Orion noted
in their article that 90% of surgeries for TOS are successful, they also
concede this means 10% of surgeries are not. They explained that in their
experience, these 10% of surgeries occur most often in patients who are over
the age of 40, have had symptoms for a long period of time, smoke, or have
other pain-causing conditions.
Even in successful
surgeries, though, complications can occur. One mentioned by Drs. Fresichlag
and Orion in their article is a pneumothorax, or collapsed lung, which in their
experience occurs in about 10% of cases. Treatment for this complication
involves using a chest tube overnight to re-inflate the lung.
Other possible
complications of TOS surgery are common to any surgery. For example, patients
can be allergic to the
disinfectant soap
used prior to surgery. Anti-itch steroidal cream can treat this complication
successfully.
Another possible
complication that can occur with the armpit approach is rare and can occur with
any thoracic surgery requiring the arm to be pulled overhead. This
complication, an injury to the axillary nerve, results in a painful condition
called quadrilateral space syndrome. Luckily, as
reported in the Annals
of Thoracic Surgery, for about 75% of patients with the condition, physical
therapy is the only needed treatment.
Certainly this is not
an exhaustive list of possible complications. Before having any surgery,
patients should review the risks and benefits with their surgeon. With a 90%
success rate and most complications occurring 10% of the time or less, TOS
surgery seems to be relatively safe and worth the risks for patients who have
not found relief through non-surgical treatments. Odds for a successful surgery
can be increased by choosing a top surgeon for treatment, many of whom wrote
the textbook
on the condition, now in its second edition.